In this study, an ambient–spark–produced–Au– nanoparticle–laden nitrogen gas was mixed with an atomized solution of 1–hexanethiol [CH3(CH2)5SH] and ethanol (EtOH). By increasing the thiol concentration from 0.1% to 1.0% (v/v), the size distribution of merged particles (Au–thiol) was changed from bimodal to unimodal configuration. The latter phenomenon is attributed to quantitative incorporation of Au nanoparticles into atomized particles. Measurements of cell viability and transfection revealed that even though the merged particles had a higher cytotoxicity (~78% in cell viability > ~49% for polyethyleneimine, PEI) than that did chitosan (~96%), the transfection (2.56 × 106 in RLU mg-1) of gene was higher than those for chitosan (7.63 × 104 ) and PEI (6.84 × 105 ).
DOI: 10.1021/cm300601m
Keywords: Aerosol fabrication, Thiol-capped Au nanoparticle, Gene transfection
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